ProfDavid Henshall

Professor

Physiology and Medical Physics

  • Professor
    Physiology and Medical Physics
  • 01 4028629 (Work)
  • RCSI, Physiology & Medical Physics, 123 St Stephens Green, Dublin 2

RESEARCH OVERVIEW

Professor Henshall's laboratory is studying cell and molecular mechanisms of epilepsy. His research team combines cell and molecular biology techniques, data science and bioinformatics, pharmacology, neuroscience and behaviour, imaging and histology, and employs a range of experimental and human models.

 

The main research interests of his group are: (1) the role and therapeutic potential of non-coding RNA (including microRNA) in epilepsy; (2) Epigenetics and signalling pathways underlying endogenous programmes of neuroprotection; (3) circulating biomarkers of seizures and epilepsy; (4) Stereo-EEG based integration of molecular and neurophysiology data in presurgical epilepsy patients.

GRANTS

  • FUNDED PROJECT
    CONTACTS – Characterizing Epilepsy Outcomes via Neurophysiological and Transcriptomic Analysis of stereoEEG Contacts
    Health Research Board / HRB5 Oct 2026 - 4 Oct 2029
  • FUNDED PROJECT
    Characterize anti-seizure effects of IV-delivered vector-mediated NaV1.1 rescue therapy in mouse models of Dravet syndrome
    Industry – Fully Funded Collaborative Research – Company owns IP6 Jul 2026 - 31 Jul 2027
  • FUNDED PROJECT
    Characterize anti-seizure effects of IV-delivered vector-mediated NaV1.1 rescue therapy in mouse models of Dravet syndrome
    Industry InKind – Fully Funded Collaborative Research – Company owns IP6 Jul 2026 - 31 Jul 2027
  • FUNDED PROJECT
    Accelerating translation of a microRNA therapy for epilepsy in pet dogs: Acronym 'K9mirsen' (K9 microRNA-ASO for Epilepsy)
    Enterprise Ireland15 Jun 2026 - 14 Jun 2027
  • FUNDED PROJECT
    Translational Development of a novel microRNA-335 Therapy for Drug-Resistant Epilepsy Using Human Models
    Industry – Co-Funded Collaborative Research – RCSI owns IP1 Jan 2026 - 31 Dec 2027
  • FUNDED PROJECT
    Translational Development of a novel microRNA-335 Therapy for Drug-Resistant Epilepsy Using Human Models
    Research Ireland1 Jan 2026 - 31 Dec 2027
  • FUNDED PROJECT
    Investigating the Anticonvulsant and Anti-Epileptogenic Potential of METTL3/14 Activation
    Industry – Co-Funded Collaborative Research – RCSI owns IP1 Aug 2025 - 31 Dec 2026
    People funded by this grant:
    • Gary B
  • FUNDED PROJECT
    Investigating the Anticonvulsant and Anti-Epileptogenic Potential of METTL3/14 Activation
    Industry InKind – Co-Funded Collaborative Research – RCSI owns IP1 Aug 2025 - 31 Dec 2026
    People funded by this grant:
    • Gary B
  • FUNDED PROJECT
    Whole cell spatial profiling of the mouse hippocampus after treatment with a disease-modifying microRNA therapy for drug-resistant epilepsy
    Science Foundation Ireland (SFI)7 Jul 2025 - 31 Aug 2026
  • FUNDED PROJECT
    FutureNeuro_Phase2 - Innovate for Ireland Supplement
    Research Ireland1 Mar 2025 - 28 Feb 2029
  • FUNDED PROJECT
    National Neurology Education Lead
    Beaumont Hospital1 Mar 2025 - 30 Mar 2027
  • FUNDED PROJECT
    My Moving Brain – Community Event
    Various Sources18 Feb 2025 - 17 Feb 2026
  • FUNDED PROJECT
    Determine the effectiveness of an AAV9-delivered miR-335 to excitatory neurons on seizures in a preclinical model of drug-resistant focal epilepsy
    Industry - Industry Funded Non-Economic Research – RCSI owns IP13 Feb 2025 - 12 May 2026
  • FUNDED PROJECT
    Determine the effectiveness of an AAV9-delivered miR-335 to excitatory neurons on seizures in a preclinical model of drug-resistant focal epilepsy
    Industry InKind – Industry Funded Non-Economic Research – RCSI owns IP13 Feb 2025 - 12 May 2026
  • FUNDED PROJECT
    Research Ireland (formerly IRC) 2025 Supplementary Stipend
    Research Ireland1 Jan 2025 - 31 Dec 2025
  • FUNDED PROJECT
    Research Ireland (formerly SFI) 2025 Supplementary Stipend
    Research Ireland1 Jan 2025 - 31 Dec 2025
  • FUNDED PROJECT
    Student Selected Projects (SSP) 2025
    RCSI1 Jan 2025 - 31 Aug 2025
  • FUNDED PROJECT
    Clinical Conference 2025 Support Funds
    Industry - Industry Funded Non-Economic Research – RCSI owns IP1 Sep 2024 - 18 May 2025
  • FUNDED PROJECT
    RCSI Soochow CSC Joint PhD Programme 2024 cohort
    RCSI1 Sep 2024 - 30 Sep 2028
  • FUNDED PROJECT
    A microRNA therapy for drug-resistant epilepsy in canines
    Enterprise Ireland19 Aug 2024 - 18 Nov 2024
  • FUNDED PROJECT
    Outcomes of rapid drug intervention on seizures in a preclinical model of temporal lobe epilepsy
    Industry - In Kind13 Jun 2024 - 31 Dec 2026
  • FUNDED PROJECT
    Outcomes of rapid drug intervention on seizures in a preclinical model of temporal lobe epilepsy
    Industry - Cash13 Jun 2024 - 31 Dec 2026
  • FUNDED PROJECT
    Targeting METTL3 and aberrant m6A methylation for the treatment of temporal lobe epilepsy
    Industry - Cash16 Apr 2024 - 31 Aug 2026
    People funded by this grant:
    • Gary B
  • FUNDED PROJECT
    Targeting METTL3 and aberrant m6A methylation for the treatment of temporal lobe epilepsy
    Industry - In Kind16 Apr 2024 - 31 Aug 2026
    People funded by this grant:
    • Gary B
  • FUNDED PROJECT
    Determine the in vivo effects of Neumirna’s antimir targeting miR-134 on behavioral co-morbidities in mice with drug-resistant epilepsy
    Industry - In Kind1 Feb 2024 - 31 Mar 2025